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KMID : 0363320160370010008
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Journal of Korean Oriental Internal Medicine
2016 Volume.37 No. 1 p.8 ~ p.15
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A Single Oral Dose Toxicity Test of GST in Beagle Dogs
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Lee Chul-Wha
Yang Won-Kyung
Jung In-Chul
Jin Mi-Rim
Kim Seung-Hyung
Park Yang-Chun
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Abstract
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Objectives: To provide information on the safety of GST (Gami-Sasangja-tang), we carried out a single oral dose-increasing
toxicity test of GST in beagle dogs.
Materials and Methods: Six beagle dogs (three males and three females) were randomly assigned to two groups
(experimental group: n=4, control group: n=2). The experimental group (two males, two females) was given oral doses of
GST in increasing order (1,250, 2,500, and 5,000 mg/kg) at three-day intervals. After administration, the participants’ mortality,
clinical signs, and body weight changes were monitored for two weeks. After two weeks, all dogs were sacrificed for autopsy.
Results: Temporary vomiting was observed according to increasing dosage (n=1, 250 mg/kg; n=4, 2,500 and 5,000 mg/kg).
Transient diarrhea was observed on the second and third dosing day (n=1, 2,500 mg/kg; n=2, 5,000 mg/kg). Temporary
salivation was noted on the third dosing day (n=3, 5,000 mg/kg). Compound-colored stool was observed in all dogs fed the
GST on all dosing days and also on the following days. We found no mortality and no abnormalities in the clinical signs, body
weight, and gross findings in any of the dogs tested.
Conclusions: The maximum tolerated dose was over 5,000 mg/kg for both male and female dogs.
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KEYWORD
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GST (Gami-Sasangja-tang), safety, single oral dose-increasing toxicity, beagle dogs
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